Peripheral blood stem cell donation
On four consecutive days before peripheral blood stem cell (PBSC) donation, a donor will receive daily injections of mobilising agents to increase the number of stem cells in their blood. Some donors may experience bone pain and flu-like symptoms, which usually respond to medication. However, less than 1% of donors experience a serious side effect as a result of PBSC donation. Most registries collect data on the health of donors following donation and, to date, WMDA is unaware of any long-term complications directly associated with GCSF injections.
Another potential risk may arise from the placement of a central line: some donors do not have suitable arm veins and must have a central venous line (a sterile tube) inserted into one of their larger veins. However, the risks of serious complications from this are small. A central line will only be placed with donor’s consent, once they have received information about the possible risks.
WMDA has established a committee, consisting of doctors, cord blood experts, and legal advisors, that evaluates serious adverse events and reactions related to donation and transfusion of blood stem cells.